Offer
Partner Role:
Partner
Topic of the offer:
Glycomics. Glycoproteomics, Proteomics, cell line and Bioinformatics
Competences offered:
Immunology.
Nano-formulation
Genomics
Offer
Partner Role:
Partner
Topic of the offer:
I am interested in otolaryngic issues particularly temporal bone imaging to better see the inner ear structures, presbiacusis(hearing loss due to aging), nanotecnology usage for regeneration of hair cells, nontoxic nanomaterials showing anatomic structures (nerves, vessels, etc) during surgery to decrease the risk of complications.
Competences offered:
I can work in the field in both in vitro and in vivo experiments as a physician (ENT surgeon)
Offer
Partner Role:
Partner
Topic of the offer:
* Gene Therapies strategies for Rare Diseases
* CAR-T cell development for Cancer Immunotherapy
* CRISPR gene editing approaches for Rare Diseases
* Virus vector including Lentivirus and Adeno-Associated Virus (AAV) production for gene therapies
* Primary focused rare diseases including spinal muscular atrophy (SMA), retinitis pigmentosa (RP), and recessive non-syndromic deafness
Other information:
- First name, Surname: Cihan Tastan
- Institution/organisation: TRANSGENIC CELL TECHNOLOGIES AND EPIGENETIC APPLICATION AND RESEARCH CENTER/ Uskudar University, Istanbul
- Country: Turkey
- E-mail: cihan.tastan@uskudar.edu.tr
- Website: https://cihantastan.academia.edu/
Competences offered:
* CRISPR gene modification techniques
* Immune profiling (peripheral blood mononuclear cell and cytokine profiling)
* CAR-T cell development
* Virus production
* Cell culture techniques
* Primary T cell culturing and modifications
* Laboratory opportunities, Flow cytometer, ELISA, RT-PCR, xCelligence Real Time Cell Analyzer, Fluorescence microscopy and Molecular biology (Western blot, PCR, RT-PCR, qPCR)
Offer
Partner Role:
Partner
Topic of the offer:
BEIA is a R&D performing SME, founded in 1991, and one of the leading providers of ICT solutions and services in the Balkan/Danube region for cloud communications and IoT telemetry. The company’s references include over 5,000 turn-key projects for advanced IT and communications solutions. BEIA is certified ISO 9001, 14001, 18001 and 27001.
We are active in the following domains:
- service innovation (AI, blockchain, cloud, big data, quantum, etc.)
- hardware (sensors, actuators, IIoT, IoMT, etc.)
- information technologies (data analytics, processing back end, interfaces, front end)
- integration (software/hardware), communication technologies (speech processing, chatbots, ASR/TTS, NLP/NLU, AI, sentiment analysis, emotional computing, contact centers, tele-systems)
- learning & training, standardization, communication / dissemination / marketing, business development, consultancy, project management.
Also, BEIA has experience in coordinating and participating in more than 40 R&D and Innovation projects (FP6, FP7, Structural Funds, H2020, ECSEL/Artemis, Eureka, Eurostars, Celtic, ITEA, COST, AAL, ERA-Net, Interreg, LIFE+, Erasmus+, MSCA, EaP Twinning, JTIs, etc.). http://www.beia.eu
Geographically, BEIA covers the Balkan/Danube region with offices in Austria, Belgium and Romania, and as fields of activities we target ICT solutions in the following domains: local and central administration, cities and municipalities, industry, agriculture, energy sector, environmental protection, public health, education and culture, national defense and intelligence. Also, BEIA has over 50 medical stakeholders as customers (hospitals, clinics, pharmacies, pharmaceutical drugs producers, etc.)
BEIA has implemented and integrated IoT telemetry applications in the field of :
- e-health (tele-diagnosis, tele-medicine, emergency communication systems for patients, nurses and doctors)
- environment (monitoring of water, soil and air quality)
- smart buildings (monitoring HVAC, light, smart power plugs, location based services using beacons, digital signage using ePaper)
- smart city (noise, air quality, mobility)
Some other IoT/Telemetry use cases (including blockchain, AI and quantum security) we are implementing are presented here: http://eng.beia-telemetrie.ro
Other information:
- First name, Surname: George Suciu
- Institution/organisation: BEIA Consult International
- Country: Romania
- E-mail: george@beia.eu
- Website: https://www.beia.eu
Competences offered:
Medical IoT systems and sensors for smart health
R&D and C&D&E experience from previous projects (STAMINA, ArtiPred, Inno4Heatlh, D4Health, ESTABLISH, SAFECARE, Mad@Work, FoodFriend, TORCH, PIMEO-AI, etc.): www.beia.eu
Offer
Partner Role:
Coordinator
Topic of the offer:
extract active components or L-asparaginase from several fungi as pure form and encapsulated with nano materials for cancer treatment
Competences offered:
applied mycology, nanotechnology, purification compounds, TLC and column chromatography, enzymology, tissue culture
Offer
Partner Role:
Partner
Topic of the offer:
- Synthesis of precious metal nanoparticles with defined sizes and shapes tailored to customer specifications
Other information:
- First name, Surname: Anna Stępień
- Institution/organisation: 3D-nano
- Country: Polska
- E-mail: astepien@3d-nano.com
- Website: https://3d-nano.com/en/
Competences offered:
3D-nano - innovative SME, which uses nanotechnology to manufacture nanomaterials, i.e. precious metal nanoparticles with defined sizes and shapes tailored to customer specifications and used in i.e. medical diagnostic, photovoltaic and electronics. Currently, we are a partner in research project focused on application of silver/gold nanoparticles with designed morphology in diagnostic of neurological diseases. We propose to participate as a partner in consortium. Contact: aolszewska@3d-nano.com
Offer
Partner Role:
Partner
Topic of the offer:
Nanosize star block copolymers as drug carriers for cancer therapy has been synthesized and investigated in terms of drug loading capacity and biodegradability. Multiarm star block copolymers with impressively high drug loading capacity has potential to be targeted by novel conjugation method with multivalent metal ions. Cell culture tests and pre-clinical studies of metal-ion conjugated and drug loaded nanoparticles are required.
Other information:
- First name, Surname: Ethel Morhayim
- Institution/organisation: Lior Kimya Sanayi ve Ticaret Ltd Sti
- Country: Turkey
- E-mail: ethel.morhayim@ilmor.com.tr
- Website: www.ilmor.com.tr
Competences offered:
Production of biodegradable star-block copolymers and characterization of neat, conjugated and drug loaded nanoparticles by Gel Permeation Chromatography, FTIR, Differential Scanning Calorimetry and Thermal Gravimetric Analysis, hydrodynamic radius measurements by Dynamic Light Scattering, determination of drug loading capacity and drug release profiles by High Performance Liquid Chromatography.
Offer
Partner Role:
Partner
Topic of the offer:
neural and stem cells for drug or scaffold applications
Other information:
- First name, Surname: Ihsan Kara
- Institution/organisation: SANKARA (Brain and Biotechnology Research Center)
- Country: Turkey
- E-mail: sankaraenator@gmail.com
- Website: https://www.sankara.com.tr
Competences offered:
We are an SME in Turkey. Our research team comprises neuroscientists, molecular biologists, biotechnologists, and chemists at different levels (Ph.D., M.Sc., and MD) and is experienced in cell culture and in vivo models for small molecule applications. We offer our expertise on pluripotent stem cells, mesenchymal stem cells, and different types of neural cells differentiated from stem cells for their use in drug or scaffold applications. Other stem cell differentiations (e.g. adipogenic, chondrogenic, and osteogenic) may also be offered. Our SME also has expertise in the extraction of plant-sourced natural flavonoids and their encapsulation.
Offer
Partner Role:
Partner
Topic of the offer:
Diagnostics
Targeted delivery systems
Competences offered:
Biological drug synthesis (mAbs, ADCs) and characterization (UPLC, CE, LC-MS/MS, SPR, ELISA etc.) , in vitro and in vivo experiments, exosome isolation and characterization, diagnostic kit production
Offer
Partner Role:
Coordinator
Topic of the offer:
Field of interest:
1.Biocompatibility assessment of materials proposed for tissue engineering
2.Biological characterization of stem cells on scaffolds
Competences offered:
• Cell culture techniques
• primary cells especially mesenchymal stem cells
• Biocompatibility assessment for organic and inorganic materials
• 2D and 3D culture systems
• Histological processing and staining
• Flow cytometer
• Fluorescence microscopy
• Molecular biology (Western blot, PCR, RT-PCR, qPCR)
Offer
Partner Role:
Coordinator
Topic of the offer:
I am looking for partners to test the diagnostic device, which will be developed by the support of the project proposal, validate and use as end-user. Clinicians and Medical Doctors are invited to collaborate to test, use, give feedback and develop these devices and technologies.
Competences offered:
As soon as we form a consortium for the EuroNanoMed3 proposal, As a coordinator I would like to develop CRISPR-Cas and aptamer based miniaturized electronic diagnostic devices. These miniaturized devices will be capable of detecting liquid biopsy markers such as circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA) and RNAs. In this proposal, CRISPR-Cas system will detect tumor DNAs and RNAs. Aptamer based system will also detect CTCs. The whole system will detect tumor heterogeneity, mutation, origin of the tumor and metastasis. All in all the diagnostic system is able to monitor diagnosis, prognosis and the treatment progress by measuring these materials. That is I can provide for the technology development. I can provide technology to develop point-of-care diagnostic device. I have knowledge more than 10 years on this area.
Offer
Partner Role:
Coordinator
Topic of the offer:
Scaffolds for dental regeneration
Other information:
- First name, Surname: Francisco Javier Rodríguez Lozano
- Institution/organisation: University of Murcia
- Country: Spain
- E-mail: fcojavier@um.es
- Website: https://orcid.org/0000-0002-0623-740X
Competences offered:
The primary investigator of the project belongs to the research group "Hematology, Hematopoietic Transplantation and Cell Therapy" (reference E037-14) of the University of Murcia. This group has part of the necessary means to carry out the experiments proposed in the project. These are found in the Hematology and Dental Materials Research Laboratories of the University of Murcia. Additionally, the animal facility of the Faculty of Medicine and radiological and microscopy services of the CEIB-LAIB of the University of Murcia will be used, specifically the service of sample preparation, SEM and CLSM microscopy. To perform the qPCR, a CFX96 Touch ™ thermocycler from LAIB Area of Molecular Biology: Genomics and Proteomics will be used. In addition, SEM, Rx diffractometer and software for phase analysis will be used.
Offer
Partner Role:
Partner
Topic of the offer:
We are a research group of academicians specialized in analytical chemistry, biochemistry and physics. We are interested in fabricating magnetic nano particulate drug delivery systems with different composite nanomaterials. Our work is composed of the design and characterization of the nano-carrier system, toxicology and biocompatibility assessment of the nano carrier and the in vitro application of the system for targeting drugs using external magnetic field.
Competences offered:
-Expertise in the study of magnetic properties, magnetic configuration, superparamagnetism, magnetic dipolar and exchange interactions, Mössbauer Spectroscopy.
-Experitse in the chemical synthesis of nanobio-composite materials for drug targeting applications.
-Expertise in the in vitro toxicity and biocompatibility assessment of nano materials used for drug targeting.
(Some of the techniques we use; HPLC, Mössbauer Spectroscopy, UV-Vis Spectrophotometer, FTIR, MTT, LDH, ROS techniques)
Offer
Partner Role:
Partner
Topic of the offer:
Development of micro and nanoscale biomaterials and 3D bioprinting applications
Competences offered:
Our team focuses on developing biocompatible and cross-linkable micro/nanoscaled technologies to push forward novel 3D scaffold tissue constructs.
Offer
Partner Role:
Partner
Topic of the offer:
3D and 4D printing and bioprinting.
Other information:
- First name, Surname: Pinar Yilgor Huri
- Institution/organisation: Ankara University
- Country: Türkiye
- E-mail: phuri@ankara.edu.tr
- Website: http://mtelab.ankara.edu.tr/
Competences offered:
We develop biomimetic strategies for engineering of tissues including bone, skeletal muscle and parathyroid.
We use advanced manufacturing techniques, 3D bioprinters and tissue culture bioreactors to generate our biomimetic grafts and investigate methods to regulate stem cell fate.
Offer
Partner Role:
Partner
Topic of the offer:
Targeted delivery systems
Competences offered:
Nanoparticle synthesis and characterization, in vitro, in vivo, in silico analyses
Offer
Partner Role:
Partner
Topic of the offer:
Design and fabrication of microfluidic devices by maskless UV lithography and 3D printing using the materials PDMS, PMMA, Glass and Printing Resin. The chips can be integrated with optical and impedance sensors.
Other information:
- First name, Surname: Serhat Sevli
- Institution/organisation: Nehir Biyoteknoloji Ltd.
- Country: Turkiye
- E-mail: bilgi@nehirbt.com.tr
- Website: https://www.ufluidic.com
Competences offered:
- Microfluidic chip fabrication
- Organ-on-a-chip development
- Microfluidic device actuation
- Integrated impedance sensors
- Mobile phone applications for microfluidic instruments
Offer
Partner Role:
Partner
Topic of the offer:
Drug development, Micro/nano encapsulation for improved drug delivery, Micro/nano drug formulations design, Real time oral drug biodistribution visualisation with NIR fluorescent imaging tecgnique, Bioavailability enhancement for low permeabl and soluble drugs, Drug targeting, Controlled release, Designing LBDDS formulations compatible with solubility characteristics of drugs (tailor made drug), Sustainable, economical and reproducible Celiac disease animal models, drug induced animal experiment modelling.
Competences offered:
Drug development, Micro/nano encapsulation for improved drug delivery, Micro/nano drug formulations design, Real time oral drug biodistribution visualisation with NIR fluorescent imaging tecgnique, Bioavailability enhancement for low permeabl and soluble drugs, Drug targeting, Controlled release, Designing LBDDS formulations compatible with solubility characteristics of drugs (tailor made drug), Sustainable, economical and reproducible Celiac disease animal models, drug induced animal experiment modelling.
Offer
Partner Role:
Partner
Topic of the offer:
My group is workin on fabrication of zwitterionic surface functionalization of polyurethane for catheter application in which anticoagulant mechanism based on Factor V and X is considered. If considered we are willing to cooperate in this manner.
Competences offered:
Polymer synthesis and functionalization and administration in medical field.
Offer
Partner Role:
Partner
Topic of the offer:
Design and micro-nanostructuring of devices and systems, including smart sensors, micro and nano- bio technology.
Other information:
- First name, Surname: Angela Mihaela BARACU
- Institution/organisation: National Institute of Research and Development for Microtechnology
- Country: Romania
- E-mail: angela.baracu@imt.ro
- Website: www.imt.ro
Competences offered:
I am a young researcher (PhD in Electronics) and part of a multidisciplinary group, with both young and experienced researchers. The National Institute for RD in Microtechnologies -IMT, where I work as a full-time researcher is an internationally competitive organization, involved in world class research in his area of activity: micro and nanoelectronic components and systems, including smart sensors, micro and nano- bio technology. I have been involved as key person in more than 5 EU projects (FP7, M.-ERANET, COST and EEA & Norway Grants), more than 12 national projects and I was the project responsible for a national project (contract with industry), gaining experience also in project management.
These are the following activities that I and my group can perform in IMT, for this call:
o The design and micro-nanostructuring of devices and systems using both photolithography and EBL of:
- transducers for electrochemical sensors, immunosensors and biosensors with various applications in environmental, biomedical and pharmaceutical fields;
- SAW structures for biosensor application in medical field and chemical sensors.
- MEMS devices with application in biosensor application in medical field and RF switches
- metasurfaces for biosensor application in medical field or spectroscopic sensors.
o Morphological characterization and analysis of surfaces at nanometre scale (AFM, SEM, XRD, FTIR, Raman)
o Electrochemical characterization of the (bio)sensors using cyclic Voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, differential pulse voltammetry techniques
The final deliverable may lie in TRL4/5: a prototype fully characterized and lab-validated.
Offer
Partner Role:
Coordinator
Topic of the offer:
Membrane-cell like nanovesicles for the management of viral infections.
Successful entry of a virus into its host cell requires a complex series of steps that begin with the viral attachment to its cellular receptors. We hypothesize that the use of membrane-cell like nanovesicles could be useful for the control of viral infections.
Competences offered:
We have wide experience in the evaluation of antiviral molecules, as the first step in their clinical development, as well as in the characterisation of their cytotoxicity and potential mechanism of action. Also, we have experience in animal models (hamster) for evaluating safety and efficacy of these molecules in the treatment of viral infections.
We have laboratories and animal facilities with all the necessary equipment to work with BSL-2 pathogens.
Offer
Partner Role:
Partner
Topic of the offer:
In vivo, ex vivo and organoid testing of advanced therapies. We are specialized in model testing of target delivery molecules as host of the Nanoimaging Unit belonging to the network NANBIOSIS-Unique Scientific Technological Infrastructures. NANBIOSIS provides a complete integrated cutting-edge biomedical advance solutions for companies and research institutions under a single contact point through the design and production of biomaterials, nanomaterials and their nanoconjugates, its characterization from a physic-chemical, functional, toxicological and biological (preclinical validation) point of view, focused on biomedical applications such as: IVDs, medical devices, biosensors, regenerative medicine, drug delivery systems, therapeutic agents or MRI contrast agents.
As a group especializad in mechanism of disease and modeling in BIONAND, we are able to perform a whole research pipeline for testing and in vivo validation of advanced therapies.
Other information:
- First name, Surname: Ivan Duran
- Institution/organisation: Andalusian Centre for Nanomedicine and Biotechnology-BIONAND. University of Malaga
- Country: SPAIN
- E-mail: ijduran@uma.es
- Website: https://www.bionand.es/nano-imaging-unit
Competences offered:
Bionand’s Nanoimaging Unit brings together a wide range of cutting-edge technologies, including high-field magnetic resonance imaging and spectroscopy, micro-CT, intra-vital optical imaging, electron microscopy, advanced optical microscopy, cell sorting and high content screening. The unit has been conceived and optimized to provide very diverse and integrated technological support for nanotechnology-based biomedical research, offering advance services to internal and external users.
As research group, we can develop and use tissue engineering and murine in vivo models as the first phase of the pipeline and as nanoimaging infrastructure unit we can measure outputs and offer a full interpretation of the results.
Offer
Partner Role:
Partner
Topic of the offer:
We are a group of researchers (PhD in Chemistry and engineers) with experience in the development of coupled techniques of High Performance Thin Layer Chromatography (HPTLC) and mass spectrometry (MS) for the characterization of complex molecular samples in different sectors such as medicine (biomarkers in biological samples such as blood, urine), pharmacology and forensic toxicology (drug detection analysis), as well as in others such as food, fossil based-fuels, biofuels, etc.
Regarding to medicine sector, we have a wide experience in blood testing for the identification of lipids as biomarkers (sphingolipids, phospholipids, lysosphingolipids) in order to facilitate the diagnosis and the monitoring of different diseases (such as lysosomal storage diseases).
All members of our group has been involved in R&D projects funded by European Commission as well as the Government of Spain.
Contact persons: Carmen Jarne (cjarne@icb.csic.es) and José Manuel Escuín (jmescuin@icb.csic.es)
Other information:
- First name, Surname: Cebolla Burillo Vicente
- Institution/organisation: Carbon Chemistry Institute (ICB). Spanish National Research Council (CSIC)
- Country: Spain
- E-mail: cjarne@icb.csic.es
- Website: http://www.icb.csic.es/
Competences offered:
We have experience in:
- Development of HPTLC separation methodology of compounds in complex molecular systems with a wide polarity range
- Development of HPTLC detection methodology by densitometry evaluation in absorption and/or induced fluorescence mode (based on intensity changes of certain fluorophores such as primulin, berberin, coralin, etc.)
- Quantification methods in order to quantify the separated and detected compounds (by HPTLC) in target samples
- Development of identification methodology by coupling of HPTLC with a Mass Spectrometer. We have experience in different ionization techniques such as Electrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI), matrix-assisted laser desorption/ionization (MALDI) and desorption electrospray ionization (DESI), as well as the fragmentation of the generated ions by MS/MS and the and the analyzer quadrupole-TOF (Time of Flight)
Offer
Partner Role:
Partner
Topic of the offer:
In our laboratory, we focus on elucidating the signal transduction mechanisms of the vessel wall, in particular the endothelium, and the generation of specific PUFA- derived metabolites that are potential endothelium-derived hyperpolarizing factors (EDHFs). Current projects aimed to elucidate the role of cytochrome lipid mediators in vascular homeostasis and dilation that affects blood pressure.
Competences offered:
To this proposal, we offer a platform for measuring delivery to specific organelles in human endothelial-cells and micro-vessels, including mechanistic studies that can detect the effect of the delivered substances to the specific target.
These include biochemical studies, phosphorylation, Ions fluxes, confocal microscopy,
electrophysiological studies, vascular reactivity studies in micro-vessels extracted from mice/rats model, using pressure myograph.
Offer
Partner Role:
Partner
Topic of the offer:
Improvement of biocompatibility and antimicrobial properties on metallic, ceramic and polymeric materials of interest for regenerative medicine via surface laser treatment.
Other information:
- First name, Surname: Albena Daskalova
- Institution/organisation: Bulgarian Academy of Sciences
- Country: Bulgaria
- E-mail: femtosciencegroup@gmail.cpm
- Website: http://femtosciencegroup.eu/
Competences offered:
The multidisciplinary team of Femto Science Application Group offers expertise in ultra-short laser treatment aiming to create surfaces which topography ensures enhanced biocompatibility, in terms of wettability, cell adhesion, cell migration as well as antimicrobial properties.
Morphology characterization (SEM, AFM), chemical composition analysis (Raman) and in vitro cell studies are performed on the laser-structured materials.
Offer
Partner Role:
Partner
Topic of the offer:
Nano Targeted therapies made of protein, lipid, polymer and hybrid materials against several diseases particular cancer
Competences offered:
For fabrication and characterization: Zeta Potential, Cyclic Voltammetry, Photo reactor with different irradiation wavelengths, High Performance Picosecond Fluorescence Lifetime Spectrometer, High temperature muffle furnace, Deionized water (milli-Q-integral 5 system), Distilled water, Double distilled water. Transmission electron microscopy, Grinding and Polishing machine, Ultra Ttome, Scanning electron microscopy, Atomic force microscopy, X-ray diffraction, Particle size analyzer& Zeta-Potential (Brookhaven), UV-Vis absorption spectroscopy, Spectro-fluorometer, Nanotest, Picosecond time correlated single photon counting, FTIR, Thermogravimetric analysis, Differential thermal analysis, Electro spinning Machine, Microwave for synthesis, Ball Mill, Freeze dryer, Oven up to 1600 °C, Drying Oven with vacuum pump, Digital pH- meter, Digital Balance up 200 g capacity, Ultrasonic bath, Vortex 3000 rpm, Rotator shaker, UV lamp, Rotary evaporator, Hot Plate with Magnetic Stirrer, Nano-fiber-electro-spinning System (MECC NANON), Contact angel& Topography (Biolin Scientific), NOVA SURFACE AREA AND PORE SIZE BY GAS SORPTION, Vibrating Sample Magnetometer (VSM), Cyclic Voltammetry, Photo reactor with different irradiation wavelengths,
For cell culture and molecular biology: Liquid nitrogen container for cell lines storage. Inverted fluorescence microscopy, Incubator CO2, Western blot apparatus, -80C deep freezer, Gel documentation system, Thermogradual PCR, Electrophoresis chamber, Homogenizer system, Centrifuge, Cold centrifuge 14000 rpm, Vortex, 4 digital balance, Hot plate magnetic starrier, Autoclave Sterilization Vertical Standard model
For histopathology techniques: Microtome, Incubator, Paraffin wax dispenser, Paraffin ribbon water bath floating, Refrigerator, Animal house, Hot magnetic plate starrier.
nemany hanafy
nemany.hanafy@gmail.com
Offer
Partner Role:
Partner
Topic of the offer:
The expertise of our research group concerns the study of magnetism of materials for biomedical and also quantum technology, data storage and cultural heritage applications by means of several experimental magnetic techniques.
Indeed our principal research field regards physical and physico-chemical studies of novel
Magnetic Multifunctional Nanoparticles for the NanoMedicine using Nuclear Magnetic Resonance (NMR), Magnetic Hyperthermia,Magnetometry and Atomic/Magnetic Force Microscopy (AFM/MFM).
Alongside the biomedical application, we use the same techniques flanked also by the Muon Spin Resonance to study: a) the magnetic properties of materials like molecular magnets and low-dimensional magnetic clusters (nanoscale systems interesting for technological applications regarding qubit, magneto-caloric effect, etc.), and b) the porosity of materials used in Cultural Heritage.
Competences offered:
NMR Relaxometry:
at room and physiological temperatures, the Nuclear Magnetic Resonance Dispersion (NMRD) profiles of magnetic materials can be studied, performing the measurements in the frequency range 10 KHz < f < 60 MHz.
Magnetic Hyperthermia:
Hyperthermic measurements working at different frequencies (range from 100 to 1000 kHz) and amplitudes (up to 17 kA/m) of the alternating magnetic field can be performed.
Atomic Force Microscopy:
Morpho-dimensional characterization can be investigated by Atomic Force Microscopy (AFM) in working temperature range 0-60 °C and eventually also in solution.
Offer
Partner Role:
Partner
Topic of the offer:
Fabrication and Characterization Targeted Therapies Loaded by Cargo Molecules Such as shDNA, siRNA, polypeptides (P17,P144), polyphenol, flavonoids, Dox.Paclitxal, cisplain against Cancer Cells and any other Diseases
Competences offered:
1-Good communications
2-Good supervision and mentor
3-bilateral projects
4-Hand by hand in parallel work
5-well documented process with no bureaucracy
6-good training students, technician and administrations
7-animal model for cancer, diabetes, inflammation as so on by using chemical process
8-Good instruments
For fabrication and characterization: Zeta Potential, Cyclic Voltammetry, Photo reactor with different irradiation wavelengths, High Performance Picosecond Fluorescence Lifetime Spectrometer, High temperature muffle furnace, Deionized water (milli-Q-integral 5 system), Distilled water, Double distilled water. Transmission electron microscopy, Grinding and Polishing machine, Ultra Ttome, Scanning electron microscopy, Atomic force microscopy, X-ray diffraction, Particle size analyzer& Zeta-Potential (Brookhaven), UV-Vis absorption spectroscopy, Spectro-fluorometer, Nanotest, Picosecond time correlated single photon counting, FTIR, Thermogravimetric analysis, Differential thermal analysis, Electro spinning Machine, Microwave for synthesis, Ball Mill, Freeze dryer, Oven up to 1600 °C, Drying Oven with vacuum pump, Digital pH- meter, Digital Balance up 200 g capacity, Ultrasonic bath, Vortex 3000 rpm, Rotator shaker, UV lamp, Rotary evaporator, Hot Plate with Magnetic Stirrer, Nano-fiber-electro-spinning System (MECC NANON), Contact angel& Topography (Biolin Scientific), NOVA SURFACE AREA AND PORE SIZE BY GAS SORPTION, Vibrating Sample Magnetometer (VSM), Cyclic Voltammetry, Photo reactor with different irradiation wavelengths,
For cell culture and molecular biology: Liquid nitrogen container for cell lines storage. Inverted fluorescence microscopy, Incubator CO2, Western blot apparatus, -80C deep freezer, Gel documentation system, Thermogradual PCR, Electrophoresis chamber, Homogenizer system, Centrifuge, Cold centrifuge 14000 rpm, Vortex, 4 digital balance, Hot plate magnetic starrier, Autoclave Sterilization Vertical Standard model
For histopathology techniques: Microtome, Incubator, Paraffin wax dispenser, Paraffin ribbon water bath floating, Refrigerator, Animal house, Hot magnetic plate starrier,
nemany.hanafy@gmail.com
Offer
Partner Role:
Partner
Topic of the offer:
We would like to be involved in a project in which a hybrid-hydrogel filler is developed for soft tissue defects due to general and/or muscolo-skeletal surgery, with the aim to avoid the third space formation causing post-operative complications, like sieromas and hematomas development, higher risk of infection and surgical wound problems.
Competences offered:
We offer our clinical and surgical competence developed in a high experienced institution, Rizzoli Orthopaedic Institute (IOR) was established in 1896 as public hospital devoted to the study and treatment of musculoskeletal disorders including tumours. IOR has over 300 beds and is the main Italian institute of orthopedics and traumatology. About 150,000 patients are examined and over 18,000 orthopedic operations occur every year. IOR is considered the leading Institution for the study and treatment of patients affected by musculoskeletal sarcomas.
Offer
Partner Role:
Partner
Topic of the offer:
DNA replication is one of the major targets of cancer therapies, as cancer cells tend to proliferate faster and are generally more prone to replication stress. We can use small molecules and peptides to manipulate DNA replication initiation in cancer cells, making them more susceptible to chemo- and radiation therapies. Identifying cancer-associated mutations in replication proteins can help create more targeted therapies. Happy to partner with medical professionals and help use patient data to develop and test novel mechanistic approaches to cancer therapy.
Other information:
- First name, Surname: Tatiana Moiseeva
- Institution/organisation: Tallinn University of Technology
- Country: Estonia
- E-mail: tatiana.moiseeva@taltech.ee
- Website: moiseevalab.com
Competences offered:
Academic partner. All DNA replication-related assays, mechanistic insights into cell cycle regulation, rates of cell proliferation and DNA synthesis, extent of DNA damage and DNA damage response, effects of the suggested therapies on protein-protein interactions.
Offer
Partner Role:
Partner
Topic of the offer:
Research ophthalmologic team with a special focus on basic and translational research in ocular surface diseases. Experience in management of biological samples, molecular analysis and cell culture techniques, along with the specializing in the collection of ocular surface samples and in the clinical-optical management of patients with corneal ectasia. Interested in participating in preclinical and clinical studies into biological mechanisms, as well as diagnostic and therapeutic nanomed applications in keratoconus.
Other information:
- First name, Surname: Uxia Regueiro
- Institution/organisation: Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS).
- Country: España
- E-mail: uxiaregueirolorenzo@gmail.com
- Website: www.linc-stgeu/contactar.aspx
Competences offered:
The research team belongs to the Clinical Neurosciences Research Laboratory (LINC) of the Health Research Institute of Santiago de Compostela, which develops its research work in collaboration with the Contactology Unit of the Instituto Galego de Oftalmoloxía (INGO). Currently our group has a research line in corneal pathology, with special dedication to the diagnosis, prognosis and clinical-optical management of corneal ectasia. This research line allows us to collect clinical data and collect biological samples from patients with corneal pathology, with the corresponding informed consents approved by the Galicia Clinical Research Ethics Committee (Code 2019/623).
We offer the possibility to participate in different studies through the following knowledge and laboratory experience: (1) Tissue preservation unit for store of biological samples (-20ºC / -80ºC); (2) Proteomics, cytometry, biochemistry and genomics units for analysis of biological samples (western blot, immunohistochemistry, HPLC, flow cytometer with sorter (FACS), centrifuges, automated DNA and RNA extraction systems, real-time thermal cyclers (PCR), reverse phase fluorescence microscope, systems for reading plates by absorbance, bioluminescence and fluorescence); and (3) Cell culture unit with laminar flow cabin, incubator, inverted microscope, cryogenic preservation systems.
We also offer the capacity to include clinical evaluation and biological sample collection of a range of patients with contact lenses, with particularly large population of keratoconus patients, through the following knowledge and clinical experience: (1) Patient consultation and exploration units (biomicroscope, refraction unit, topographer, aberrometer, tomographer); (2) Contactology room for the adaptation of contact lenses; (3) Ante-operating room for extraction of biological samples and -20º freezer for temporary storage of samples.
Offer
Partner Role:
Partner
Topic of the offer:
expertise in the etiopathogenesis of Type 1 diabetes and autoimmune polyendocrine syndromes
Other information:
- First name, Surname: Alessandra Fierabracci
- Institution/organisation: Children's Hospital Bambino Gesù
- Country: Italy
- E-mail: alessandra.fierabracci@opbg.net
- Website: orcid.org/0000-0003-3078-9754
Competences offered:
Cellular Immunology with special reference to T and B lymphocytes functional assays, molecular biology, protein chemistry, AIRE and PTPN22 genetic screening
Offer
Partner Role:
Partner
Topic of the offer:
I am interested to participate as a partner in EuroNanoMed 3 program.
Other information:
- First name, Surname: Maria Marudova
- Institution/organisation: University of Plovdiv "Paisii Hilendarski"
- Country: Bulgaria
- E-mail: marudova@uni-plovdiv.net
- Website: uni-plovdiv.bg
Competences offered:
1. development of polyelectrolyte multilayers, polyelectrolyte complexes, nano and micro carriers for drug delivery.
2. QCM and SPR techniques for sensing.
Offer
Partner Role:
Partner
Topic of the offer:
We are a multidisciplinary group, with both young and experienced researchers. For this call, we can design and develop microfabricated sensors and biosensors for the qualitative and quantitative determination of biomarkers from biological samples. The institute where I work as a full-time researcher is one of the main institutes in Romania, with high international visibility, and participation in European projects (www.imt.ro). IMT provides a professional environment, full scientific and managerial support, and a variety of equipments necessary for this research topic.
Other information:
- First name, Surname: Dr. Livia Dinu
- Institution/organisation: National Institute of Research and Development for Microtechnology (IMT-Bucharest)
- Country: Romania
- E-mail: livia.dinu@imt.ro
- Website: www.imt.ro; http://postdoc-research.eu;
Competences offered:
These are the following activities that we can do in IMT, for this call:
- Synthesis of carbon-based materials and metallic nanoparticles, morphological, and structural characterization of the synthesized materials
- Atomic Layer Depostion thin films depositions (and lots of other techniques) www.imt.ro ;
- Micro- nano-fabrication of electrodes, transducers
- Electrical, morphological, and structural characterization (SEM, AFM, XRD, FTIR, Raman) of the electrodes
- Design of electrochemical sensors and biosensors
- Electrochemical, optical, and morphological characterization of the (bio)sensors
- Method validation in lab conditions.
Offer
Partner Role:
Partner
Topic of the offer:
In vitro (cell models) and in vivo studies (mouse models) for assessing the host immune response, as well as the antimicrobial and safety properties of new therapies in nanomedicine against bacterial pathogens (i.e. Mycobacterium and Staphylococcus spp.) and for evaluating and cytotoxic, genotoxic and toxicological effects of nanomaterials after chronic or acute exposure.
Other information:
- First name, Surname: Cinzia Marianelli
- Institution/organisation: Istituto Superiore di Sanità (ISS)
- Country: Italia
- E-mail: cinzia.marianelli@iss.it
- Website: www.iss.it
Competences offered:
Expertise in the pathogenesis of bacterial infections, especially those affecting animals, such as mycobacterial agents (Mycobacterium bovis and Mycobacterium avium complex) and bovine mastitis pathogens (straphylococcus and streptococcus spp.), and the host response to infectious agents at the molecular, cellular, and whole-animal level.
Expertise in animal models (mice and rats) for evaluating toxicological parameters and genotoxic (DNA damage) effects after nanoscale agent exposure.
We have cellular and molecular laboratories, and microbiology BSL-2 and BSL-3 laboratories, as well as animal facilities.
Offer
Partner Role:
Partner
Topic of the offer:
Synthesis of bioactive compounds and synthesis of drug-conjugates for targeted drug delivery based on peptides, steroids, carbohydrates or other small molecules that recognize upregulated receptors of cancer cells.
Competences offered:
-Consult companies on targeted drug delivery
-Design, synthesis and development of new targeted drug delivery systems for targeted delivery and theragnostics
Offer
Partner Role:
Partner
Topic of the offer:
The MAT4LL group expertise includes the development of devices and materials for the monitoring of CECs and other organics in liquid samples mainly. Nanomaterials such as metal-organic frameworks, ionic liquids and derivatives, and hybrid materials are incorporated in micro-devices for analyses.
Other information:
- First name, Surname: Verónica Pino
- Institution/organisation: Universidad de La Laguna
- Country: Spain
- E-mail: veropino@ull.edu.es
- Website: http://mat4all.webs.ull.es
Competences offered:
We offer new alternatives to the classic analytical sample pretreatment methods and the ability to perform sampling, extraction, preconcentration and monitoring of CECs in waters and other samples with higher complexity such as biological samples.
Offer
Partner Role:
Partner
Topic of the offer:
Our company develops synthetic polypeptide-based materials starting from natural amino acids. We use N-carboxyanhydride polymerization (NCA) technique to obtain poly(amino acid)s i.e. synthetic polypeptides. NCA polymerization is also the method for the producton of the famous multiple sclerosis (MS disease) complex drug called copolymer-1 (i.e. glatiramer acetate, Copaxone). Recently, we combined NCA technique and recently explored triazolinedione click chemistry to obtain hydrogels and films from synthetic polypeptides. NCA technique is advantageous over solid phase peptide synthesis (SSPS) in terms of scalability, cost and polymer lenght. On the other hand, TAD chemistry is advantageous over other click chemistry reactions as this reaction does not require catalyst, UV, heat or byproducts.
We specifically focus drug delivery, RNA delivery and tissue engineering applications as our materials will have superior advantage over traditional polymers and hydrogels. We can provide products with varying range of amino acid composition, different mechanical properties and tunable porosity of the hydrogel network.
Other information:
- First name, Surname: Saltuk Hanay
- Institution/organisation: Hanay Advanced Chemicals / Sabanci University Nanotechnology Research and Application Center
- Country: Turkey
- E-mail: saltuk.hanay@sabanciuniv.edu
- Website: https://hanay-ac.com/
Competences offered:
We can provide poly(amino acid)s and hydrogels for drug delivery, RNA delivery and tissue engineering applications. Our method is flexible so that we can work with partners to develop new formulations for specific applications.
Offer
Partner Role:
Partner
Topic of the offer:
In vitro (cell models) and in vivo studies (mouse models) for assessing the host immune response, as well as the antimicrobial and safety properties of new therapies in nanomedicine against bacterial pathogens (i.e. Mycobacterium and Staphylococcus spp.) and for evaluating and cytotoxic, genotoxic and toxicological effects of nanomaterials after chronic or acute exposure.
Other information:
- First name, Surname: Cinzia Marianelli
- Institution/organisation: Istituto Superiore di Sanità
- Country: Italia
- E-mail: cinzia.marianelli@iss.it
- Website: www.iss.it
Competences offered:
Expertise in the pathogenesis of bacterial infections, especially those affecting animals, such as mycobacterial agents (Mycobacterium bovis and Mycobacterium avium complex) and bovine mastitis pathogens (straphylococcus and streptococcus spp.), and the host response to infectious agents at the molecular, cellular, and whole-animal level.
Expertise in animal models (mice and rats) for evaluating toxicological parameters and genotoxic (DNA damage) effects after nanoscale agent exposure.
We have cellular and molecular laboratories, and microbiology BSL-2 and BSL-3 laboratories, as well as animal facilities.
Offer
Partner Role:
Partner
Topic of the offer:
We develop well-defined size controlled polymer nanoparticles in the range from 5-10 nm (single chain polymer nanoparticles) as well as larger sizes from 20 to 200 nm (controlled crosslinking polymerization). We can render these nanoparticles biocompatible and endow them with practically any functionality (sugars/glucose, peptides, fluorescence labels, click chemistry), and we are evaluating these for brain uptake.
Competences offered:
- Well-defined size controlled polymer nanoparticles on multi-gram scale;
- In vitro blood barrier model to evaluate transport of nanomaterials
- Characterization techniques (NMR, HPLC-GPC equipped with UV, fluorescence detector, etc.)
Offer
Partner Role:
Partner
Topic of the offer:
The title: A nucleotide-modified RNA-aptamer, selected to the self-surface of human B-cell lymphoma cell, as the targeting moiety for delivery of therapeutic molecules.
We have generated nucleotide-modified RNA-aptamers (nmRNA-aptamers) (80 - 100 nt oligonucleotides) that recognize the cell-surface molecules of malignant B-cell lymphoma (Burkitt lymphoma, BL) cells, using the Whole-Cell SELEX method modification (Cell-SELEX-FA) elaborated by us previously. Viability tests have demonstrated that one of the selected nmRNA-aptamers (at concentration 4.0 µM) inhibited cell proliferation of the all studied highly malignant CD10+ BL lines (n=5) from 56% up to 99%. The same nmRNA-aptamer (nmRNA-apt) was inactive in T-cell lymphoma cell lines and normal donor lymphocytes. Soft-Agar-Growing Test has also demonstrated significant inhibition of the cell-colony formation of the CD10+ BL lines by this nmRNA-apt. We assumed that the selected nmRNA-aptamer can be suggested as the carrier molecule to target malignant B cells for delivery of therapeutic molecules.
The aim of the WP#: investigation of potential therapeutic application of the generated nmRNA-aptamer as the targeting moiety for delivery of therapeutic molecules in human B-cell lymphoma model.
The methodology will include the study: (1) using the panel of human high-malignant B-cell lymphoma cell lines (BCLs) versus the EBV-immortalized non-malignant lymphoblastoid B-cell lines (LCLs); (2) on the panel of human cancer cell lines of different tissue origin and (3) using the peripheral blood samples from healthy individuals and patients with B-cell lymphomas, diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).
Expected results of the WP#: to work out the protocol (dozes per malignant cell, input incubation time-schedule) by which both the highest BCL cell-proliferation blocking effect and the lowest toxic effect for non-malignant B cells will be achieved in order to suggest the new developed strategy, based on the application of the nmRNA-aptamer complex and the elaborated protocol, for the treatment of patients with high-grade aggressive B-cell lymphomas.
Competences offered:
Task 1.1. Production of nmRNA-apt and the control nmRNA-NN (random sequences), using a previously developed protocol, in amounts needed for generation of nmRNA-aptamer complexes and the following in vitro experiments;
Task 1.2. Verification of specific cell-proliferation blocking property of the prepared nmRNA-apt and the control nmRNA-NN by MTT test, using reference cell lines (B-cell lymphoma, T-cell lymphoma, and EBV-immortalized non-malignant lymphoblastoid B-cell lines, LCL) and the panel of human cancer cell lines of different tissue origin (monocytic, cervix, breast, colon, lung, kidney, stomach);
Task 2.1. To work out the protocol (dozes per cell, input incubation time-schedule) by which both the highest B-cell lymphoma cell-proliferation blocking effect and the lowest toxic effect for non-malignant B cells will be achieved for the nmRNA-aptamer complexes, in comparison with the free nmRNA-apt and the control nmRNA-NN, using cell lines (B-cell lymphoma, T-cell lymphoma, and LCL);
Task 2.2. (Optional, financing-depended) Evaluation of the in vivo toxicity in mice (biodistribution and tissue toxicity) of the nmRNA-aptamer complexes, in comparison with the free nmRNA-apt and the control nmRNA-NN;
Task 3. Verification of the malignant-B-cell specificity of the nmRNA-aptamer complexes, in comparison with the free nmRNA-apt and the control nmRNA-NN, using the peripheral blood of patients with B-cell lymphomas, diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), applying the aptamer 5’-end FITC-labeling and the multiparameter flow cytometry analyses (BD FACSAriaIII).
Offer
Partner Role:
Partner
Topic of the offer:
Nobel Pharmaceuticals is one the leading pharmaceutical company in Turkey. We are looking for a partnership for upcoming EuroNanoMed3 call.
We are searching for a partnership opportunities for development and usage of nanocarrier systems for one of the existing mammalian cell based biotechnological drugs in the market. We can contribute for the production and nanocarrier based formulation of biotechnological drugs in GxP environment. Our current capabilities could enable validation in relevant areas which enables co-development of TRL 3-6 projects in pharmaceutical drug field.
Other information:
- First name, Surname: Selim SÜLEK
- Institution/organisation: Nobel Pharmaceuticals
- Country: Turkey
- E-mail: selim.sulek@nobel.com.tr
- Website: www.nobel.com.tr
Competences offered:
As Nobel, we are working on mammalian cell based production of monoclonal antibodies and protein for therapeutic usage. We could be a part in development about nanocarriers, bioreactor, newly developed purification systems and process based on microfluidics, artificial intelligence in therapeutic areas. We also want to be a part of project in nanotechnology field related with life science and/or pharmacy. We can have direct contribution for comparison of traditional methods vs newly developed methods and also full characterization of end products of mammalian cell based products. We could be a partner for projects that are TRL 3-6 level.
Briefly What We can Offer:
• Upstream and Downstream Process Development
• Antibody and protein characterization
• Epitope Mapping, interaction and kinetic with SPR and/or Octet Systems.
• Physicochemical and biochemical analysis and method development
• GMP Production
• Industrial Cell Line
• Ready to use Upstream and Downstream process for several molecules
• Collaborating in developing new technology or advancement in available one.
• Testing of new technology or devices.
• Re-development of process and procedures for better economical and health profits
Offer
Partner Role:
Partner
Topic of the offer:
Topic of the offer:
Field of interest:
1. Skin regeneration
2. bone and cartilage repair/regeneration,
MAJOR RESEARCH INTEREST OF THE GROUP
• Biocompatibility assessment of materials proposed for bone and skin engineering
• The potential of MSC secretome for wound and osteo-articular regenerative therapy
• Development of skin and bone 3D organotypic cultures for in vitro study of therapeutic compounds
Other information:
- First name, Surname: Irina Titorencu
- Institution/organisation: Institute of Cellular Biology and Pathology Nicolae Simionescu
- Country: Romania
- E-mail: irina.titorencu@icbp.ro
- Website: www.icbp.ro
Competences offered:
• Cell culture techniques
• Biocompatibility assessment for organic and inorganic materials
• 2D and 3D culture systems
• Histological processing and staining
• Ultracentrifugation techniques for exosomes isolation
• Fluorescence microscopy
• Molecular biology (Western blot, PCR, RT-PCR, qPCR)
Offer
Partner Role:
Partner
Topic of the offer:
Topic of the offer:
Field of interest: cardiovascular research
MAJOR RESEARCH INTEREST OF THE GROUP
• Modulation of angiogenesis
• Regenerative therapy
• Stem cells
Other information:
- First name, Surname: Ana Maria Rosca
- Institution/organisation: Institute of Cellular Biology and Pathology Nicolae Simionescu
- Country: Romania
- E-mail: ana-maria.rosca@icbp.ro
- Website: www.icbp.ro
Competences offered:
• Mesenchymal stem cells
• Biocompatibility assessment
• 2D and 3D culture systems
• Histological analysis
• Fluorescence microscopy, confocal microscopy
• Molecular biology (Western blot, PCR, RT-PCR, qPCR, transfections)
• Biochemistry techniques
• In vivo angiogenesis assay
Offer
Partner Role:
Partner
Topic of the offer:
- Biocompatible and biodegradable polymeric nanocarriers for Regenerative medicine and
Target delivery.
- Biocompatible and biodegradable polymeric nanocarriers modified with metallic
nanoparticles for Theragnostics (Regenerative medicine, Target delivery, and diagnostics)
- Metallic nanoparticles with surface modifications for Drug Delivery, Diagnostics, and
Theranostics.
Other information:
- First name, Surname: Jose Luis Muñoz Gómez
- Institution/organisation: LEITAT
- Country: España
- E-mail: jlmunoz@leitat.org
- Website: https://www.leitat.org/
Competences offered:
• Rational design, synthesis, and characterization of smart nanocarriers regarding the route of
administration of the final formulation.
• Design, synthesis, and characterization of biofunctionalized inorganic nanoparticles with
specific responses for medical diagnosis, therapy, theranostics, and biosensing
• Release studies under relevant reconstructed biological fluids.
• Stability testing based on durability sustained release and transformation of the
nanosystems and the final formulations in biologically relevant environments.
Offer
Partner Role:
Partner
Topic of the offer:
- animal models of stroke, intracerebral hemorrhage, and gliobastoma (in mice or rat)
- in vitro, and in vivo MRI studies for diagnosis and therapy (9.4 T, Bruker System)
- characterization of new contrast agents for MRI and cell tracking
Other information:
- First name, Surname: Ramón Iglesias-Rey
- Institution/organisation: Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS)
- Country: Spain
- E-mail: ramon.iglesias.rey@sergas.es
- Website: www.linc-stg.eu/contactar.aspx
Competences offered:
We offer the possibility to participate in different studies through the following knowledge and experience
1) Experimental and Behavioral Animal Unit: Animal housing for rodents with all necessary resources to house 150 rats and 60 mice.
2) Surgery Unit: Four fully equipped surgery rooms for rodents, with gaseous anesthesia, stereotaxic frames, surgery microscopes, electrocoagulation, Doppler blood flow-meter, infusion pumps, thermal control units, etc.
3) Tissue Preservation Unit: -80ºC preservation cabins for preservation of tissue samples, cryostats for preparation of histological sections, and a reverse phase fluorescence microscope for immuno-histochemical analysis
4) Cell Culture Unit: Laminar flow cabin, incubator, experimental ischemia system (chamber of oxygen and glucose deprivation of cell cultures), inverted microscope, cryogenic preservation systems a -80ºC, access to confocal microscopy.
5) Nanoparticle Processing Unit: reactor, a shaker and a sounding bath for processing of iron nanoparticles. Rotavapor coupled to extruder for the elaboration of liposomes.
6) Molecular Imaging Unit (MRI): with a state-of-the-art MRI system of 9.4 Tesla (Bruker Biospin) for rodents, equipped with animal monitoring systems. The use of this platform in its different variants: anatomical, and molecular imaging spectroscopy allows progression of the disease, noninvasive (in vivo) and longitudinal time-related processes related to neurovascular diseases such as plasticity, reorganization or neurorepair and functional recovery in animal models. Neuroimaging and Cardiac magnetic resonance imaging are available for this system.
Offer
Partner Role:
Partner
Topic of the offer:
- skin tissue engineering, 3D culture (tumor spheroids)
- extracellular matrix remodeling
- electroporation or polymeric micelles for drug delivery
Other information:
- First name, Surname: Laure Gibot
- Institution/organisation: CNRS IMRCP (academic)
- Country: France
- E-mail: gibot@chimie.ups-tlse.fr
- Website: http://imrcp.ups-tlse.fr/
Competences offered:
original human skin tissue engineering based on self-assembled approach, so no exogenous material, rich in endogeneous extracellular matrix.
Studies at tissue scale (skin substitute or tumor spheroids)
Chemical and biological tools to analyse extracellular matrix remodelling
drug delivery via physical approach (electroporation) or chemical ones (self-assembled polymeric micelles)
Offer
Partner Role:
Partner
Topic of the offer:
Despite their functional similarity to protein antibodies, oligonucleotide aptamers have many unique properties that are suitable for clinical applications and industrialization. Aptamers can be use in fields such as biomarker discovery, in vitro and in vivo diagnosis, precisely controlled drug release and targeted therapy. Aptamers have been used successfully in therapy (Pegaptanib), in diagnostic platforms and as a biotechnological tool.
Other information:
- First name, Surname: Miguel Moreno
- Institution/organisation: Aptusbiotech
- Country: Spain
- E-mail: miguel.moreno@aptusbiotech.com
- Website: http://en.aptusbiotech.com/
Competences offered:
Aptus Biotech is a biotech start-up R&D performing SME whose main goal is the development of new biotechnological applications based on aptamer technology. Aptamers are artificial nucleic acid ligands (short single-stranded RNA or DNA) that present high association constants with target proteins, relatively easy and reproducible production and labelling, cost-effectiveness and stability during long-term storage. Aptamer technology is an innovative alternative and much less known than that of monoclonal antibodies. This technology provides multiple applications in biotechnology, health, agriculture-food industry and other sectors.
Specifically, as a successful case in aptamers R&D, Aptus carried out the initial stages of the development and characterization of an aptamer against TLR4 . Firstly patented by the company (PCT/EP2015/064277), in 2017, AptaTargets purchased the molecule and initiated the ApTOLL program towards the treatment of acute ischemic stroke. Currently, the molecule is in clinical trials phase IIa.
Offer
Partner Role:
Partner
Topic of the offer:
Clinical center specializing in cancer care, along with preclinical oncology research facilities through partner institution (IFOM). Interested in participating in preclincial, and clinical studies into biological mechanisms, as well as diagnostic and therapeutic nanomed applications in oncology.
Other information:
- First name, Surname: Paul Summers
- Institution/organisation: Istituto Europeo di Oncologia
- Country: Italy
- E-mail: paul.summers@ieo.it
- Website: www.ieo.it
Competences offered:
A range of cancer patient groups in care, with paritcularly large populations of breast and prostate cancer patients. A leader in low dose CT screening, prostate, breast and whole-body MRI, and mammography services. Specialist robotic surgery and radiotherapy services.
Offer
Partner Role:
Partner
Topic of the offer:
Tissue engineering, coatings
Other information:
- First name, Surname: Juan Antonio Ruiz Fuentes
- Institution/organisation: Nadetech Innovations
- Country: España
- E-mail: juanan.ruiz@nadetech.com
- Website: www.nadetech.com
Competences offered:
-Customization of coating devices based on several techniques
-NovaSpider: 3D bioprinting and more (www.novaspider.com)
Offer
Partner Role:
Partner
Topic of the offer:
Magnetism of nanostructures, with particular reference to magnetic nanoparticles and nanocarriers for nanomedicine applications (magnetic hyperthermia, drug delivery and release, tissue regeneration).
Other information:
- First name, Surname: Lucia Del Bianco
- Institution/organisation: Department of Physics and Earth Sciences - University of Ferrara
- Country: Italy
- E-mail: lucia.delbianco@unife.it
- Website: http://docente.unife.it/lucia.delbianco
Competences offered:
- Expertise in the study of magnetic hysteretic properties, magnetic configuration and spin canting, magnetization processes, thermal stability and superparamagnetism, magnetic dipolar and exchange interactions.
- Expertise in the phenomenology of magnetic heating from magnetic nanoparticles subjected to an alternating magnetic field.
- Experience in the use of SQUID magnetometer, in Mössbauer spectroscopy and calorimetric and thermogravimetric analysis (DSC-TGA).
Offer
Partner Role:
Partner
Topic of the offer:
Diagnostics or drug delivery
Other information:
- First name, Surname: Aristeidis Bakandritsos
- Institution/organisation: Regional Centre of Advanced Technologies and Materials
- Country: Czech Republic
- E-mail: a.bakandritsos@upol.cz
- Website: https://www.rcptm.com/
Competences offered:
We offer:
-Imaging agents (MRI, photoacoustic, fluorescent, PET/SPECT)
-Nanomaterials for electrochemical and fluorescent sensing platforms
-Nanotheranostics and photothermal therapy agents
-Antibacterial agents against resistant bacteria
Offer
Partner Role:
Partner
Topic of the offer:
Elvesys is a French innovative SME dedicated to flow management and microfluidic instrumentation. We design the microfluidic system that will meet the specific needs of your application (e.g. innovative health care, point of care testing, diagnosis, drug testing, …), and automate fluid handling tasks for your project. We already bring our expertise to more than 30 European projects, we would be glad to help you to develop the innovative microfluidic setup that fits your project needs.
Other information:
- First name, Surname: Noémi Thomazo
- Institution/organisation: Elvesys
- Country: France
- E-mail: partnership@elvesys.com
- Website: https://www.elveflow.com
Competences offered:
Microfluidics
Flow control at microscale
Lab-on-chip for diagnostics
Organ-on-chip to study disease mechanisms and test new drugs
Offer
Partner Role:
Partner
Topic of the offer:
Elvesys is a French innovative SME specialized in microfluidic instrumentation and flow control. We are interested to join a consortium of the upcoming EuroNanoMed3 call. In particular, we can contribute to the development of lab-on-chips for analysis of chemicals, or organ-on-chip platforms to evaluate the toxicity of pollutants on health.
We will be happy to discuss further!
Other information:
- First name, Surname: Christa Ivanova
- Institution/organisation: Elvesys SAS
- Country: France
- E-mail: christa.ivanova@elvesys.com
- Website: www.elveflow.com
Competences offered:
Microfluidics, Lab-on-chip, Organ-on-chip, Dissemination, Single Cell Encapsulation, Parallelization of Experiments, Miniaturization of Laboratory Assays
Offer
Partner Role:
Partner
Topic of the offer:
Mammalian cell transfection systems, suitable for the therapeutic protein production. Our transfection method is based on cell penetrating peptide (CPP) mediated delivery of nucleic acid and is applicable to mammalian cell factories (large scale protein production) with much higher efficacies compared to the current state-of-the-art commercial protein production platforms.
Competences offered:
Chemical biology: Chemical synthesis of peptide / polymer -based transfection components.
Cell biology: Transfection in mammalian cell cultures. Cell culture screening models, applicable in the context of large scale therapeutic protein production.
Offer
Partner Role:
Partner
Topic of the offer:
- development of recombinant protein binders using selection from highly complex scaffold libraries as high-affinity ligands for in vitro and vivo diagnostics
- development of non-cognate protein ligands targeted to broadly neutralizing antibodies as viral epitope mimetics useful as immunogens for vaccine development
- generation of protein blockers with neutralizing potential
Other information:
- First name, Surname: PETR MALY
- Institution/organisation: Institute of Biotechnology of the Czech Academy of Sciences, v.v.i.
- Country: Czech Republic
- E-mail: petr.maly@ibt.cas.cz
- Website: https://www.ibt.cas.cz/en/
Competences offered:
- selection of protein scaffold variants using ribosome display from highly complex combinatorial libraries (scaffolds with randomized loops, beta-sheets or three helix bundle)
- biophysical, biochemical and functional characterization of binding proteins
- protein engineering with directed evolution or rational design
- modification of proteins, affinity maturation, tailor-made proteins
Offer
Partner Role:
Partner
Topic of the offer:
Smartphone-based diagnostics for point-of-care testing in various matrices
Other information:
- First name, Surname: Aristeidis Tsagkaris
- Institution/organisation: University of Chemistry and Technology in Prague
- Country: Czech Republic
- E-mail: tsagkara@vscht.cz
- Website: https://uapv.vscht.cz/?jazyk=en
Competences offered:
• Biosensors: Methods development, validation and benchmarking
• 3D-printing, fabrication of lab-on-a-chip devices with integrated functions
• Use of smartphones as analytical detectors for ubiquitous sensing
• Instrumental analysis for example liquid chromatography coupled to high resolution mass spectrometry, for biosensor result confirmation
Offer
Partner Role:
Partner
Topic of the offer:
- nano or microstructured wound dressings for chronic wounds healing based on nanofiber mats and lipide particles for controled release kinetics
- semiproduction machine for microfluidic preparation of lipide drug capsules
- impragnation of implants with different type of active substance (and its structures)
- antibacterial surfaces based on silver particles
Other information:
- First name, Surname: Taťána Fenclová
- Institution/organisation: ING Medical s.r.o.
- Country: Czech Republic
- E-mail: tatana.fenclova@ingmed.cz
- Website: www.ingmed.cz
Competences offered:
- wound dressings with active formulation with encapsulated active substance
- spray atomization of nano/microparticel dispersions and liquids on modulate production line
- electrospinning of nanofiber mats for wound covers
Offer
Partner Role:
Partner
Topic of the offer:
Testing of interaction of different nanomaterials - nanoparticles and surfaces with nanotopoghrapy - with different cell types (primary cells, cell lines - immune cells, bone cells, mesenchymal stem cells).
Test of new implants.
Test of nanoparticles for delivery or for modulation of immune system.
Competences offered:
Cell culture tests of cell viability, metabolism, adhesion, expression, release of cytokines, exosomes using advanced techniques - confocal and electron microscopy, flow cytometry analysis, biochemical and molecular biological methods
Offer
Partner Role:
Partner
Topic of the offer:
Fullerene nanomaterials for CRISPR-Cas9 delivery
Competences offered:
We are looking for partners in the field of genome editing. We offer engineered fullerene nanomaterials which are already active for siRNA transfection. We are looking for biologically oriented partners with expertise in CRISPR-Cas9 techniques.
Offer
Partner Role:
Partner
Topic of the offer:
Trace and ultra-trace metals (total and speciation) analysis, Nanomaterials (NMs) characterization (nanoparticles and nanomedicines), analytical method development and validation
Other information:
- First name, Surname: Menta Mathieu
- Institution/organisation: Ultra Traces Analyses Aquitaine - UT2A / ADERA
- Country: France
- E-mail: mathieu.menta@univ-pau.fr
- Website: www.ut2a.fr
Competences offered:
The analytical equipment of the laboratory is composed of Mass Spectrometers and Atomic Emission Spectrometers by Induced Plasma Coupling (ICP-MS and ICP-AES), associated separation systems (High Performance Liquid Chromatography / HPLC, Gas Chromatrography / GC), and equipment dedicated to the characterization of NMs such as DLS, AF4-MALS-ICPMS and spICP-MS.
For nearly ten years, UT2A has acquired skills in NMs characterization in the fields of food, cosmetics, environment and health. The laboratory has thus been involved in various research projects related to quality assurance or quality control (QUACHA, TRAP, SWIFT), speciation analysis (ELISA) and nanomedicines (NANOPILOT - H2020).
Since 2010, UT2A has set up a quality environment based on the Good Laboratory and Manufacturing Practices (GLP/GMP). This standard has been implemented within UT2A through various concrete actions such as the drafting of a quality assurance manual, the traceability of samples, analyses and results, the metrological control of laboratory equipment. UT2A is regularly audited by different companies. These audits allow UT2A to work according to a high-performance quality system in continuous improvement.
Competences offered:
- Multi-dimensional physico-chemical characterization of polymers and nanoformulations by A4F-UV-MALS-(RI or ICPMS) online : granulometry (size, size distribution), shape, aggregation state, stability, encapsulation efficiency, chemical composition
- Determination of size and concentration of metallic nanoparticles by Single particle ICPMS
- Granulometry by DLS according to ISO reference document.
- Analytical method development and validation expertise in a nearly GLP implemented environment together with external QA audits.
- Trace metals impurities in pharmaceutical products according to ICHQ3D
- Speciation and trace metal analysis by HPLC and GC-ICPMS
Monforte de Lemos 5, 28029 – Madrid, Spain
era@isciii.es
Ignacio Baanante
+34 9182 22576